lets prevent

Let's Prevent Diabetes - Update

Thanks to everyone who took at interest in the study, we have recruited our target of 748 people!

People in the study are still attending clinic sessions and
will continue to do so through 2013 and into 2014, with the last participant scheduled for their final visit in July 2014. We hope to publish our first results in about 18 months time, although some of the early findings have already been presented at scientific conferences in the UK and in Europe - details listed below.

Let’s Prevent is funded by a National Institute for Health Research (NIHR) programme grant

What is this study about?


Let’s Prevent is the first randomised controlled study looking at whether an educational lifestyle programme (of diet and exercise) can prevent those with a condition called pre-diabetes going on to develop diabetes.

Diabetes and impaired glucose tolerance are increasingly appearing in younger people and, before the onset of diabetes, most people will have some degree of abnormal glucose tolerance, as has been found in previous screening studies such as STAR & ADDITION.

The most efficient way to address the problem of diabetes and its complications is to prevent diabetes from developing.

Research on patients with impaired glucose tolerance has shown that prevention is possible, particularly using lifestyle modification interventions.

The aim of the study is to establish whether the use of a structured lifestyle modification programme (based on the DESMOND programme) prevents those with pre-diabetes going on to develop diabetes.

What happens in the study?


We know there are some things that make people more at risk of getting diabetes such as being overweight or having high cholesterol so we will be screening the practice data to identify those people at risk of developing diabetes. Our aim was to recruit approximately 50 GP practices to the study and the patients identified as more at risk were invited to attend a screening session where they were tested for pre-diabetes. Only those patients diagnosed with pre-diabetes entered the study.

Each practice was randomised (like the toss of a coin) to either the educational intervention (structured lifestyle modification programme) or control arm of the study and patients from the practice received treatment accordingly. Those patients in the practices randomised to the educational intervention were invited to attend an educational session of either one 6-hour or two 3-hour sessions initially, followed by an optional yearly refresher session. Patients in the practices randomised to the control arm received standard patient care and information. The educational sessions were held in small groups and, where necessary, an interpreter was available.

All participants within the study have annual health checks for 3 years and this information is passed on to their GP for their records.

How do I get involved?


Recruitment to the Let’s Prevent study is now closed. Those participating in this study continue to attend clinical visits for 3 years from when they entered the study.  The Study is still in progress and the first papers with the outcome data are due to be published after September 2014.   However the study team has had posters accepted Diabetes UK and also published papers into the initial findings and the use of the practices risk score - details listed below.

Accepted by Diabetologia for publication:

I’m participating in this study - what happens next?

Everyone participating in Let’s Prevent is in the study for 3 years and attends a follow up yearly.  Even if you are diagnosed with diabetes, you stay in the study.  It is important to monitor those that have been identified as at risk of developing diabetes. If you had been diagnosed by your GP with pre-diabetes then they should carry out blood tests and checks each year to see whether you still have pre-diabetes, whether your blood sugars have returned to normal or progressed to diabetes, and it is really important that you do have these yearly checks.   Whilst in the Let’s Prevent study, we take care of those tests – we see you for your yearly review and, at the same time, collect the information for the research study. This clinical and research information will help us to see if the educational sessions help to prevent diabetes.  


We appreciate that it is time consuming to attend clinic for a morning so if you are too busy to attend an appointment with us then your GP can carry out the main tests and share the results with us.  We can also send you the questionnaires in the post for completion.  However, unless you have been diagnosed with diabetes, the test your GP will do is the same (oral glucose tolerance test or OGTT) – and you will have to wait at the practice for 2 hours.  So if you attend our clinic, you can complete the questionnaires whilst you’re waiting and also have the opportunity to ask the nursing team any questions.   It’s important to note though that visits to the Lets’ Prevent study are not replacements for other clinical appointments with the GP or practice nurse. .

If you joined the study in 2009, you will soon be having your final visit and participation in the study will then end. Your GP will be notified of the results of your final tests and he/she will then be responsible for your yearly check-ups. Final visits for participants will continue through 2013 and into 2014, with the last participant scheduled for their final visit in July 2014.

When the study has finished, our findings will be published in nation research journals and hopefully help inform current clinical practices. A summary of the overall findings will be sent to you as a participant – you have helped to make the Let’s Prevent study possible and it’s important we let you know what we found.

It is very important that, whilst participating in Let’s Prevent, you do not enrol in or participate in any other (healthcare) research study or clinical/drug trial – especially ones looking at cardiovascular risk, blood pressure or cholesterol levels.  This is because that trial (whether it is taking tablets or doing some form of activity) could then interfere with or influence the results of Let’s Prevent, and vice versa.  You may be advised you can do both but, for our study, you cannot be in another trial at the same time. 
Once you have completed your participation in Let’s Prevent diabetes you can participate in other studies – either within the Leicester Diabetes Centre or elsewhere.  We run many studies, involving those with pre-diabetes, those with diabetes and those simply at risk of diabetes.  If you wish to hear about these studies then please let us know. 




For further information about Let’s Prevent please contact the team using the form below Or  contact Stephanie Goldby Senior Project Lead / Primary Care Lead 


Lets Prevent Published research

NIHR Case Study - Let\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\'s Prevent article published (2010) Download Document

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